The tissue localization of m -amsa and its effect on thymidine incorporation in various tissues in vivo
Identifieur interne : 003411 ( Main/Exploration ); précédent : 003410; suivant : 003412The tissue localization of m -amsa and its effect on thymidine incorporation in various tissues in vivo
Auteurs : B. Hellman [Suède] ; B. S. Andersson [États-Unis] ; P. Slanina [Suède] ; A. Mohammed [Suède] ; I. Brandt [Suède] ; M. Beran [États-Unis]Source :
- Medical Oncology and Tumor Pharmacotherapy [ 0736-0118 ] ; 1986-06-01.
English descriptors
- KwdEn :
- Teeft :
- 3htdr, 3htdr incorporation, 3htdr uptake, Acute leukemia, Adrenal, Adrenal cortex, Albino mouse, Antitumor, Assoc cancer, Atwell, Autoradiographic studies, Biomedical center, Bone marrow, Carcinogenic tryptophan pyrolysis product, Cell systems, Chem, Corresponding volume, Cytosine arabinoside, Deoxyribonucleic acid, Diphenylamine method, Distribution pattern, Endocrine organs, Excretion, Gastric mucosa, Glandular part, High concentration, High dose, Highest concentration, Incorporation, Inhibitory effects, Initial accumulation, Injection, Intestinal contents, Intravenous injection, Legha, Lymph nodes, Lymphoid tissues, Marrow, Metastatic melanoma, Moderate uptake, National cancer institute, Organ weight, Pancreatic islets, Physiological saline, Polypeptide hormone, Potential antitumor, Potential antitumor agents, Present study, Radioactivity, Rapid excretion, Rat, Significant amounts, Significant inhibition, Small intestine, Spleen, Strong accumulation, Thymidine incorporation, Thymus, Tissue distribution, Toxic effects, Tumor institute, Various organs, Whole body autoradiography.
Abstract
Abstract: The distribution of14C-labelledm-AMSA was studied in rats and pigmented mice using whole body autoradiography. The agent rapidly disappeared from the blood, accumulating in significant amounts in large parenchymal organs, certain endocrine tissues, and the retina of the pigmented mouse eye. The hemopoietic and lymphoid tissues showed a moderate uptake of radioactivity with the highest concentration observed in the thymus. The autoradiograms indicated a rapid excretion of radioactivity via the liver, kidney and the glandular part of the gastric mucosa. The distribution pattern of label from14C-m-AMSA remained unaffected by pretreatment of animals with high dose (500 mg kg−1 b.w.) of cytosine arabinoside. Injection of unlabelledm-AMSA (7 mg kg−1 b.w.) to growing rats 24 h before sacrifice resulted in a highly significant (P<0.001) inhibition of3H-thymidine incorporation into the DNA of thymus and spleen. A less pronounced reduction was observed in the kidney, adrenal, lung and testes. The thymidine incorporation into the DNA of bone marrow was markedly suppressed when calculated per dry weight, but increased when related to the DNA content, suggesting early regeneration of the remaining cells. In contrast, no significant effects were observed on the DNA synthesis in small intestine and liver.
Url:
DOI: 10.1007/BF02934559
Affiliations:
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Slanina</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Toxicology Laboratory, National Food Administration, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Mohammed, A" sort="Mohammed, A" uniqKey="Mohammed A" first="A." last="Mohammed">A. Mohammed</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Toxicology Laboratory, National Food Administration, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Brandt, I" sort="Brandt, I" uniqKey="Brandt I" first="I." last="Brandt">I. Brandt</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences, Biomedical Center, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Beran, M" sort="Beran, M" uniqKey="Beran M" first="M." last="Beran">M. Beran</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Hematology, University of Texas M.D. Anderson Hospital and Tumor Institute at Houston, 6723 Bertner Avenue, Box 55, 77030, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Oncology and Tumor Pharmacotherapy</title><title level="j" type="abbrev">Med. Oncol. & Tumor Pharmacother.</title><idno type="ISSN">0736-0118</idno><imprint><publisher>Humana Press</publisher><pubPlace>Totowa</pubPlace><date type="published" when="1986-06-01">1986-06-01</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="87">87</biblScope><biblScope unit="page" to="94">94</biblScope></imprint><idno type="ISSN">0736-0118</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0736-0118</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cytosine arabinoside</term><term>Tissue distribution</term><term>Whole body autoradiography</term><term>m -AMSA</term><term>thymidine incorporation</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>3htdr</term><term>3htdr incorporation</term><term>3htdr uptake</term><term>Acute leukemia</term><term>Adrenal</term><term>Adrenal cortex</term><term>Albino mouse</term><term>Antitumor</term><term>Assoc cancer</term><term>Atwell</term><term>Autoradiographic studies</term><term>Biomedical center</term><term>Bone marrow</term><term>Carcinogenic tryptophan pyrolysis product</term><term>Cell systems</term><term>Chem</term><term>Corresponding volume</term><term>Cytosine arabinoside</term><term>Deoxyribonucleic acid</term><term>Diphenylamine method</term><term>Distribution pattern</term><term>Endocrine organs</term><term>Excretion</term><term>Gastric mucosa</term><term>Glandular part</term><term>High concentration</term><term>High dose</term><term>Highest concentration</term><term>Incorporation</term><term>Inhibitory effects</term><term>Initial accumulation</term><term>Injection</term><term>Intestinal contents</term><term>Intravenous injection</term><term>Legha</term><term>Lymph nodes</term><term>Lymphoid tissues</term><term>Marrow</term><term>Metastatic melanoma</term><term>Moderate uptake</term><term>National cancer institute</term><term>Organ weight</term><term>Pancreatic islets</term><term>Physiological saline</term><term>Polypeptide hormone</term><term>Potential antitumor</term><term>Potential antitumor agents</term><term>Present study</term><term>Radioactivity</term><term>Rapid excretion</term><term>Rat</term><term>Significant amounts</term><term>Significant inhibition</term><term>Small intestine</term><term>Spleen</term><term>Strong accumulation</term><term>Thymidine incorporation</term><term>Thymus</term><term>Tissue distribution</term><term>Toxic effects</term><term>Tumor institute</term><term>Various organs</term><term>Whole body autoradiography</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The distribution of14C-labelledm-AMSA was studied in rats and pigmented mice using whole body autoradiography. The agent rapidly disappeared from the blood, accumulating in significant amounts in large parenchymal organs, certain endocrine tissues, and the retina of the pigmented mouse eye. The hemopoietic and lymphoid tissues showed a moderate uptake of radioactivity with the highest concentration observed in the thymus. The autoradiograms indicated a rapid excretion of radioactivity via the liver, kidney and the glandular part of the gastric mucosa. The distribution pattern of label from14C-m-AMSA remained unaffected by pretreatment of animals with high dose (500 mg kg−1 b.w.) of cytosine arabinoside. Injection of unlabelledm-AMSA (7 mg kg−1 b.w.) to growing rats 24 h before sacrifice resulted in a highly significant (P<0.001) inhibition of3H-thymidine incorporation into the DNA of thymus and spleen. A less pronounced reduction was observed in the kidney, adrenal, lung and testes. The thymidine incorporation into the DNA of bone marrow was markedly suppressed when calculated per dry weight, but increased when related to the DNA content, suggesting early regeneration of the remaining cells. In contrast, no significant effects were observed on the DNA synthesis in small intestine and liver.</div></front></TEI><affiliations><list><country><li>Suède</li><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="Suède"><noRegion><name sortKey="Hellman, B" sort="Hellman, B" uniqKey="Hellman B" first="B." last="Hellman">B. Hellman</name></noRegion><name sortKey="Brandt, I" sort="Brandt, I" uniqKey="Brandt I" first="I." last="Brandt">I. Brandt</name><name sortKey="Mohammed, A" sort="Mohammed, A" uniqKey="Mohammed A" first="A." last="Mohammed">A. Mohammed</name><name sortKey="Slanina, P" sort="Slanina, P" uniqKey="Slanina P" first="P." last="Slanina">P. Slanina</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Andersson, B S" sort="Andersson, B S" uniqKey="Andersson B" first="B. S." last="Andersson">B. S. Andersson</name></region><name sortKey="Beran, M" sort="Beran, M" uniqKey="Beran M" first="M." last="Beran">M. Beran</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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